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Main characteristics of CRABYON
Safety data of CRABYON

Acute Toxicity Test (Chitin)
LD 50(lethal dose 50): Over 3,000mg/Kg

The term lethal dose 50 is defined as the dose of a substance which is fatal to 50% of the test animals. More specifically. Lethal dose 50 means that if chitin is orally administred to mice on the basis of 3,000mg/Kg (mouse weight), 50% of them die.

Mutagenicity Test (Chitin)
Mutagenicity Test: Negative
This test is conducted to determine whether or not the test animals undergo an abrupt change in the genotype of organ.
Positive: Mutagenic
Negative: not Mutagenic

Skin irritation Patch Test *
Patch Test: 1B (almost negative)

To be in compliance with JAFET (Japanese Association for the Functional Evaluation of Textile), the fabric in question has to be at least almost negative.

* A test in which material is applied and left in contact with skin surfaces for 48 hours to check tissue sensivity.

Clinical tests of whether "CRABYON underwear" will improve patients of atopic dernatitis.

Purpose
The objective is to determine whether CRABYON, with many characteristics can alleviate the symptom of atopic dermatitis.

Tester of CRABYON underwear
A doctor of medicine who runs a pediatrics in Osaka, Japan.

Test Specimen
Half-sleeved underwear of blended fabric (30% Crabyon / 70% cotton).

Testees (patients)
The doctor selected 11 patients from among his outpatients, whose symptoms are relatively stable and whom he can be reach easily for consultation.
a. Test period: January to March, 1996
b. The number of testees: 11 patients
c. Age: Children of 2 year 3 month to 11 years 3 month old.

Test Method
All 11 testees wore CRABYON underwear after obtaining their parents consent. Three pieces of underwear were goven to each testees who wore them one after another and were washed after each use. The doctor and parents saw each testee every two weeks. After eight weeks, he evaluated whether or not the CRABYON underwear improved patients of atopic dermatitis.



Efficacy Evaluation

Category  
5
Improved considerably
4
Improved
3
Improved a little
2
Remain unchanged
1
Aggravated
a. Doctor'sComments
He recorded the skin conditions such as itch, dryness and scratches every two weeks and classified them into five categories:
Category  
5
Very effective
4
Effective
3
Somewhat effective
2
Not effective
1
Unknown
b. Overall Evaluation
Considering the skin conditions, use of medicine and food, he classified the underwear's effectiveness into five categories:
Test Results
2-3 years old
3 persons
3-4
2
4-5
1
5-6
1
6-7
2
7-8
-
8-9
1
9-10
-
10-
1
11 persons
a. Testees Age Group
Category
5 (improved considerably)
"0" persons
4 (improved)
2
3 (somewhat improved)
5
2 (remain unchanged)
4
1 (aggravated)
0
b. Test results
He classified the testees skin conditions as follows:

He classified the effectiveness of CRABYON underwear as follows:
Category  
5 (very effective)
1 person(s)
4 (effective)
1
3 (somewhat effective)
4
2 (not effective)
3
1 (unknown)
2
c. Side effects
All 11 testees experienced no side effects of CRABYON at the end of two month-long wear test. At the end of the test, it is considered that the CRABYON underwear is safe.

d. Time dependent change of skin conditions
Table 1 and Fig. 9 show how skin conditions changed over time. (Weighted average of five categories)

Table1 - Time dependent change of skin conditions
Itch
Scrach
Dryness
Softness
Ovall
evalution
1 day
3.82
4.09
3.91
4.36
3.00
4 week
4.36
4.64
4.27
n.d
n.d
8 week
4.45
4.64
4.36
4.36
4.00
Fig. 9